Has anyone's dog ever had any vaccine reactions and if, how severe?

Tessa had another set of shots this morning: rabies, distemper, parvo, leptospirosis, and kennel cough. Plus a microchip. Now (2-3 hours later) she has two egg-shaped lumps at the injections sites (shoulder - not where the micropchip is) and thigh. She is also acting weird: sleeping, pacing, sleeping, pacing, kinda disoriented, trying to play, lying down again, seems queasy and woosy, much like after anesthesia, trembling. But no face swelling, no hives.

Called the vet, he said to give her a benadryl and observe her for now. The trembling may have been because she felt cold, turned the heat on and the tembling subsided some, maybe due to the benadryl. The lump on her leg is huge and painful to the touch. Can I do anything about it to help it go down (compresses, ice)?

Good thing is, I live 5 minutes from the vet school so I can take her in quickly if needed. I am wondering if anyone had a situation similar to this. Never observed this on any of my dogs.

12:55 pm today...just sleeping now...if I wasn't so worried I would enjoy it and get some things done.

This is not like her 

I never had a dog that had a reaction like that, although they often get small lumps at the injections sight, but not what you are describing.  That said my mother's cocker had a bad reaction to the lepto vaccine.  She went into anaphalactic shock before they even got home.  Thankfully the got her back to the vet in time.  Bell, my oldest GSP, had a bad reaction to the bortatella nasal vaccine.  The inner part of her nostril got raw and swelled and the lymph nodes on the side of her face swelled and she fely lousy.  She now only gets the bordatella injected vaccine.  I don't do the nasal on any of my kids anymore.  I probably wouldn't do it at all except that the place I board my dogs requires it. 

I would watch her really close, especially the breathing.  If she has any problems breathing, take her back to the vet.  Good luck, and let us know how she does.

Tessa is 15 weeks. That's interesting about the lepto and GSPs. She had her first lepto on Sep. 25 with no ill affects...and another one today. I know the lepto and rabies are usually the culprits. Re lepto, my vet strongly recommends it for dogs with a lot of exposure to water sources. I guess I will do some research...

Tucker, if Ruger was 4 and the immunity should last 3-5 years he'll be a senior then...a lot of vets are now rethinking vaccinated older dogs...maybe he'll be fine then?

Hope your baby is doing better this morning.  Please let us know has she is as we are all pulling for you and her.

we had negative reactions to the Lepto vaccine as well. Next time, your vet can give her an extra shot of something to curb the reaction (I forget what it is but the vet will know), they usually only give it to smaller dogs as they believe that larger breeds don't normally suffer from that reaction.

Anyway, ours had vomiting (with some blood in it) and diarrhea (also with blood). I was rather peeved at the office as they maintained it was unlikely but they apologized for it and have been great ever since.

Update:

You blink and next thing you know one year has passed and she's due for the shots AGAIN!

Tessa was vetted up yesterday. Since she had the reaction last year, we pre-treated her with a benadryl injection, then she was given the 1-year DHPP, corona, 3-year rabies, and kennel cough (without the pre-treat she would have gotten these vaccines on different days). She also got a fecal check and heartworm-ehrlichiosis-lyme test (they test that as a batch), all negative. We scanned the microchip and it reads as and where it should.

We skipped the Lepto shot. My new vet doesn't stock it anymore because they had too many reactions, but will order and administer it upon client request. After some research, I declined. I asked some people I train with and none of them give the lepto - and their dogs are more exposed to water sources than Tessa is.

Tessa was kept at the clinic for observation but apparently she did just fine, and not even the benadryl slowed her down. When I picked her up she was 100% herself. There is not one bump on her from any of the shots. This is much different from last year. We don't know what caused the reaction then, but I suspect either too many shots at once for such a young pup, or it really was the lepto.

When I picked her up, one of the vet techs had her 12-year old  GSP at the clinic for shots, and we took them outside for a potty break. Here are Tessa & Megan: