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Subject: Re: [gsp-l] Re: [gsp-l] very important real info about LD

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woodshafengsps User is Offline

MH
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11/04/2011 8:09 AM
Very understandable Tracy. I think we would all do benefit in knowing what is going on as quick as possible, but I hate to think that Leita has the weight on her shoulders,and has to be responsible for the speed in which we all know the results. Maybe Leita can give us a "Go to" website that we can get this info for ourselves ? Laura Wood Woods Hafen GSP's From: Tracy N To: gsp-l@shorthairs.net; Dena Calivas Sent: Wednesday, September 14, 2011 7:02 AM Subject: [gsp-l] Re: [gsp-l] very important real info about LD This is very good news. I wish it had come out when I was told on this list that my clear-by-parentage was not possible. I began testing clear offspring and throwing away money. I should have stirred the pot sooner because my plea for clarification fell on deaf ears. I know we all lead busy lives but this is a critical subject for breeders and proper communication is vital! Will OFA be notified so they post the correct results? Thank you (but I'm still a little po'd about this being ignored earlier), Tracy Novoa Sent from my Verizon Wireless Phone ----- Reply message ----- From: "Leita Estes" To: "gsp-l@shorthairs.net" Subject: [gsp-l] very important real info about LD Date: Tue, Sep 13, 2011 11:40 pm This is a quote from Dr. Casal tonight. In short, we have found the gene and the mutation. The test that we have been running for the past year is the mutation test not a marker test. So our test is 99.99% accurate provided the samples have been properly labeled. Leita Estes Shortales German Shorthaired Pointers Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH # 1 GSP 2011 1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point From: Deirdre To: "gsp-l@shorthairs.net" Sent: Tuesday, September 13, 2011 7:09 PM Subject: Re: [gsp-l] very important real info about LD If my understanding is correct based on the research I do, when you state a 5% margin of error you are referring to 95% confidence interval for the test. Correct? That is still only disclosing the margin of error for the marker, not the gene? Sent from my iPhone On Sep 13, 2011, at 7:47 PM, Leita Estes <shortales@rocketmail.com> wrote: The test we have for LD at this time is the only test available and this disease is severe enough that not to test is very important for our breed it is something you as a breeder need to think very hard about. Would you really want to take the chance of producing affected puppies because you didn't test? Lets have a cool head about this and stop the negative comments until we have all the information from Dr. Casal. Dr. Casal is the expert not myself or the H&W committee or Katie Tazza so just be patient and wait for scientific information rather that rumor or hearsay. There are two types of genetic tests: a direct or gene based test wherein the actual gene is known and the actual mutation identified. This is what the CD test is an indirect or marker test in which the actual gene is not known but a piece of chromosome is associated with the disease. Marker tests always have a range of error up to 5% depending on the distance from the actual gene (in other words, the larger you cast your net on the chromosome, the greater can be the error. This is what the LD test is. The H&W committee has asked Dr. Casal if she would answer some questions for us about the development of the test and many other pertainent questions about the test. She is working on it now (in all her spare time which we need to be patient as she is very busy) and as soon as we have the information we will publish it in the Journal. Leita Estes Shortales German Shorthaired Pointers Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH # 1 GSP 2011 1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point From: Tracy N <gspfreak@aol.com> To: gsp-l@shorthairs.net Sent: Tuesday, September 13, 2011 3:14 PM Subject: [gsp-l] Re: [gsp-l] Re: [gsp-l] LD test In the event you do test and have a carrier, you should not breed it. There is no way of knowing, at this point in time, if you're truly breeding to a non-carrier and/or producing non-carriers. The gene has not been found. Sent from my Verizon Wireless Phone ----- Reply message ----- From: LahrGSP@aol.com To: <gsp-l@shorthairs.net> Subject: [gsp-l] Re: [gsp-l] LD test Date: Tue, Sep 13, 2011 5:46 pm In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time, gspfreak@aol.com writes: There is no definite "normal" either. Despite what the results say. So what is the point of doing it? Julie M. Lahr www.vonlahrheim.com Kangaroo Show Leads http://vonlahrheim.com/rooshowleads

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