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| Author |
Messages |
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shortales
MH
Posts:336
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| 11/04/2011 8:03 AM |
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The test we have for LD at this time is the only test available and this disease is severe enough that not to test is very important for our breed it is something you as a breeder need to think very hard about. Would you really want to take the chance of producing affected puppies because you didn't test?
Lets have a cool head about this and stop the negative comments until we have all the information from Dr. Casal. Dr. Casal is the expert not myself or the H&W committee or Katie Tazza so just be patient and
wait for scientific information rather that rumor or hearsay.
There are two types of genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This is what the CD test is
an indirect or marker test in which the actual gene is not
known but a piece of chromosome is associated with the disease. Marker tests
always have a range of error up to 5% depending on the distance from the actual
gene (in other words, the larger you cast your net on the chromosome, the
greater can be the error. This is what the LD test is.
The H&W committee has asked Dr. Casal if she would answer some questions for us about the development of the test and many other pertainent questions about the test. She is working on it now (in all her spare time which we need to be patient as she is very busy) and as soon as we have the information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Tracy N
To: gsp-l@shorthairs.net
Sent: Tuesday, September 13, 2011 3:14 PM
Subject: [gsp-l] Re: [gsp-l] Re: [gsp-l] LD test
In the event you do test and have a carrier, you should not breed it. There is no way of knowing, at this point in time, if you're truly breeding to a non-carrier and/or producing non-carriers. The gene has not been found.  Sent from my Verizon Wireless Phone
In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time,
gspfreak@aol.com writes:
There is no definite "normal" either. Despite what the
results say.
So what is the point of doing it?
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Hedgehog Hill
SH
Posts:47
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| 11/04/2011 8:05 AM |
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Thank you for the clarification between the two
types of testing. I have and intend to continue to test any dog I intend to
breed and will anticipate further clarification and education.
I do think it would be helpful to post clarifying information on
the website when known, even ahead of Journal publication.
I am curious as to how many dogs have been tested to date and of those
dogs, the number identified as affected, carriers or
normal.
I think this information would be helpful for people to begin to realize
that testing will only better our breed, provide some basic parameters of the
sample size as of a date certain in terms of starting to evaluate prevalence
etc.
Most of all, Thank you for all the efforts the H&W committee
are making on this particular front and others!
In a message dated 9/13/2011 7:56:50 P.M. Eastern Daylight Time,
shortales@rocketmail.com writes:
The test we have for LD at this time is
the only test available and this
disease is severe enough that not to test is very important for our breed it
is something you as a breeder need to think very hard about. Would you really
want to take the chance of producing affected puppies because you didn't
test?
Lets have a
cool head about this and stop the negative comments until we have all the
information from Dr. Casal. Dr. Casal is the expert not myself or the H&W
committee or Katie Tazza so just be patient and wait for
scientific information rather that rumor or hearsay.
There are two types of
genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This
is what the CD test is
an indirect or marker test in which the actual gene is
not known but a piece of chromosome is associated with the disease. Marker
tests always have a range of error up to 5% depending on the distance from the
actual gene (in other words, the larger you cast your net on the chromosome,
the greater can be the error. This is
what the LD test is.
The H&W committee has asked Dr.
Casal if she would answer some questions for us about the development of the
test and many other pertainent questions about the test. She is working on it
now (in all her spare time which we need to be patient as she is very
busy) and as soon as we have the
information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple
BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty
dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Tracy N
To:
gsp-l@shorthairs.net
Sent:
Tuesday, September 13, 2011 3:14 PM
Subject: [gsp-l] Re: [gsp-l] Re: [gsp-l]
LD test
In the event you do test and have a carrier, you should
not breed it. There is no way of knowing, at this point in time, if you're
truly breeding to a non-carrier and/or producing non-carriers. The gene has
not been found. Sent from my Verizon Wireless Phone
In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time,
gspfreak@aol.com writes:
There is no definite "normal" either. Despite what the
results say.
So what is the point of doing it?
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sunniefair
JH
Posts:38
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| 11/04/2011 8:05 AM |
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Leita, I would be interested in knowing how long ago the questions were sent to Dr. Casal? And how long you plan to wait for answers? I seems to me that quite a few of the GSP community have sent money for tests and we should expect timely answers to the H & W committees questions. I would also prefer to see the reply posted in its entirety on the website rather than wait months for the Journal article. Sunnie Fair
Date: Tue, 13 Sep 2011 16:47:28 -0700 From: shortales@rocketmail.com Subject: [gsp-l] very important real info about LD To: gsp-l@shorthairs.net The test we have for LD at this time is the only test available and this disease is severe enough that not to test is very important for our breed it is something you as a breeder need to think very hard about. Would you really want to take the chance of producing affected puppies because you didn't test?
Lets have a cool head about this and stop the negative comments until we have all the information from Dr. Casal. Dr. Casal is the expert not myself or the H&W committee or Katie Tazza so just be patient and
wait for scientific information rather that rumor or hearsay.
There are two types of genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This is what the CD test is
an indirect or marker test in which the actual gene is not
known but a piece of chromosome is associated with the disease. Marker tests
always have a range of error up to 5% depending on the distance from the actual
gene (in other words, the larger you cast your net on the chromosome, the
greater can be the error. This is what the LD test is.
The H&W committee has asked Dr. Casal if she would answer some questions for us about the development of the test and many other pertainent questions about the test. She is working on it now (in all her spare time which we need to be patient as she is very busy) and as soon as we have the information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Tracy N
To: gsp-l@shorthairs.net
Sent: Tuesday, September 13, 2011 3:14 PM
Subject: [gsp-l] Re: [gsp-l] Re: [gsp-l] LD test
In the event you do test and have a carrier, you should not breed it. There is no way of knowing, at this point in time, if you're truly breeding to a non-carrier and/or producing non-carriers. The gene has not been found. Sent from my Verizon Wireless Phone
In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time,
gspfreak@aol.com writes:
There is no definite "normal" either. Despite what the
results say.
So what is the point of doing it?
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LahrGSP
MH
Posts:703
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| 11/04/2011 8:05 AM |
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I was just thinking if I tested Pepper then I would have to test her babies.
If Pepper is clear then her pups could not be affected right? Sent from my iPhone...
Julie www.vonlahrheim.com
Leita, I would be interested in knowing how long ago the questions were sent to Dr. Casal? And how long you plan to wait for answers? I seems to me that quite a few of the GSP community have sent money for tests and we should expect timely answers to the H & W committees questions. I would also prefer to see the reply posted in its entirety on the website rather than wait months for the Journal article. Sunnie Fair
Date: Tue, 13 Sep 2011 16:47:28 -0700 From: shortales@rocketmail.comSubject: [gsp-l] very important real info about LD To: gsp-l@shorthairs.netThe test we have for LD at this time is the only test available and this disease is severe enough that not to test is very important for our breed it is something you as a breeder need to think very hard about. Would you really want to take the chance of producing affected puppies because you didn't test?
Lets have a cool head about this and stop the negative comments until we have all the information from Dr. Casal. Dr. Casal is the expert not myself or the H&W committee or Katie Tazza so just be patient and
wait for scientific information rather that rumor or hearsay.
There are two types of genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This is what the CD test is
an indirect or marker test in which the actual gene is not
known but a piece of chromosome is associated with the disease. Marker tests
always have a range of error up to 5% depending on the distance from the actual
gene (in other words, the larger you cast your net on the chromosome, the
greater can be the error. This is what the LD test is.
The H&W committee has asked Dr. Casal if she would answer some questions for us about the development of the test and many other pertainent questions about the test. She is working on it now (in all her spare time which we need to be patient as she is very busy) and as soon as we have the information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Tracy N <gspfreak@aol.com>
To: gsp-l@shorthairs.net
Sent: Tuesday, September 13, 2011 3:14 PM
Subject: [gsp-l] Re: [gsp-l] Re: [gsp-l] LD test
In the event you do test and have a carrier, you should not breed it. There is no way of knowing, at this point in time, if you're truly breeding to a non-carrier and/or producing non-carriers. The gene has not been found. Sent from my Verizon Wireless Phone
In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time,
gspfreak@aol.com writes: There is no definite "normal" either. Despite what the
results say.
So what is the point of doing it?
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deirdrerahn
Posts:3
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| 11/04/2011 8:07 AM |
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If my understanding is correct based on the research I do, when you state a 5% margin of error you are referring to 95% confidence interval for the test. Correct? That is still only disclosing the margin of error for the marker, not the gene?
Sent from my iPhone
The test we have for LD at this time is the only test available and this disease is severe enough that not to test is very important for our breed it is something you as a breeder need to think very hard about. Would you really want to take the chance of producing affected puppies because you didn't test?
Lets have a cool head about this and stop the negative comments until we have all the information from Dr. Casal. Dr. Casal is the expert not myself or the H&W committee or Katie Tazza so just be patient and
wait for scientific information rather that rumor or hearsay.
There are two types of genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This is what the CD test is
an indirect or marker test in which the actual gene is not
known but a piece of chromosome is associated with the disease. Marker tests
always have a range of error up to 5% depending on the distance from the actual
gene (in other words, the larger you cast your net on the chromosome, the
greater can be the error. This is what the LD test is.
The H&W committee has asked Dr. Casal if she would answer some questions for us about the development of the test and many other pertainent questions about the test. She is working on it now (in all her spare time which we need to be patient as she is very busy) and as soon as we have the information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Tracy N <gspfreak@aol.com>
To: gsp-l@shorthairs.net
Sent: Tuesday, September 13, 2011 3:14 PM
Subject: [gsp-l] Re: [gsp-l] Re: [gsp-l] LD test
In the event you do test and have a carrier, you should not breed it. There is no way of knowing, at this point in time, if you're truly breeding to a non-carrier and/or producing non-carriers. The gene has not been found. Sent from my Verizon Wireless Phone
In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time,
gspfreak@aol.com writes: There is no definite "normal" either. Despite what the
results say.
So what is the point of doing it?
|
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|
shortales
MH
Posts:336
|
| 11/04/2011 8:07 AM |
|
This is a quote from Dr. Casal tonight. In short, we have found the gene and the mutation. The test that we
have been running for the past year is the mutation test not a marker
test. So our test is 99.99% accurate provided the samples have been
properly labeled.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Deirdre
To: "gsp-l@shorthairs.net"
Sent: Tuesday, September 13, 2011 7:09 PM
Subject: Re: [gsp-l] very important real info about LD
If my understanding is correct based on the research I do, when you state a 5%
margin of error you are referring to 95% confidence interval for the test. Correct? That is still only disclosing the margin of error for the marker, not the gene?
Sent from my iPhone
The test we have for LD at this time is the only test available and this disease is severe enough that not to test is very important for our breed it is something you as a breeder need to think very hard about. Would you really want to take the chance of producing affected
puppies because you didn't test?
Lets have a cool head about this and stop the negative comments until we have all the information from Dr. Casal. Dr. Casal is the expert not myself or the H&W committee or Katie Tazza so just be patient and
wait for scientific information rather that rumor or hearsay.
There are two types of genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This is what the CD test is
an indirect or marker test in which the actual gene is not
known but a piece of chromosome is associated with the disease. Marker tests
always have a range of error up to 5% depending on the distance from the actual
gene (in other words, the larger you cast your net on the chromosome, the
greater can be the error. This is what the LD test is.
The H&W committee has asked Dr. Casal if she would answer some questions for us about the development of the test and many other pertainent questions about the test. She is working on it now (in all her spare time which we need to be patient as she is very busy) and as soon as we have the information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Tracy N <gspfreak@aol.com>
To: gsp-l@shorthairs.net
Sent: Tuesday, September 13, 2011 3:14 PM
Subject: [gsp-l] Re: [gsp-l] Re: [gsp-l] LD test
In the event you do test and have a carrier, you should not breed it. There is no way of knowing, at this point in time, if you're truly breeding to a non-carrier and/or producing non-carriers. The gene has not been found. Sent from my Verizon Wireless Phone
In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time,
gspfreak@aol.com writes: There is no definite "normal" either. Despite what the
results say.
So what is the point of doing it?
|
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shortales
MH
Posts:336
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| 11/04/2011 8:07 AM |
|
The committee sent Dr. Casal a list of over 20 questions the middle of Aug. She has been working on them and is very near to finishing. We will post them on the website as well as in the Journal for those members that don't check the website. I am glad she is taking the time to answer our questions. This will be very informative to our members to understand the process in developing the test as well as what it all means to us as breeders.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Sunnie Fair
To: GSP List
Sent: Tuesday, September 13, 2011 6:55 PM
Subject: RE: [gsp-l] very important real info about LD
Leita, I would be interested in knowing how long ago the questions were sent to Dr. Casal? And how long you plan to wait for answers? I seems to me that quite a few of the GSP community have sent money for tests and we should expect timely answers to the H & W committees questions. I would also prefer to see the reply posted in its entirety on the website rather than wait months for the Journal article. Sunnie Fair
Date: Tue, 13 Sep 2011 16:47:28 -0700 From: shortales@rocketmail.com Subject: [gsp-l] very important real info about LD To: gsp-l@shorthairs.net The test we have for LD at this time is the only test available and this disease is severe enough that not to test is very important for our breed it is something you as a breeder need to think very hard about. Would you really want to take the chance of producing affected puppies because you didn't test?
Lets have a cool head about this and stop the negative comments until we have all the information from Dr. Casal. Dr. Casal is the expert not myself or the H&W committee or Katie Tazza so just be patient and
wait for scientific information rather that rumor or hearsay.
There are two types of genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This is what the CD test is
an indirect or marker test in which the actual gene is not
known but a piece of chromosome is associated with the disease. Marker tests
always have a range of error up to 5% depending on the distance from the actual
gene (in other words, the larger you cast your net on the chromosome, the
greater can be the error. This is what the LD test is.
The H&W committee has asked Dr. Casal if she would answer some questions for us about the development of the test and many other pertainent questions about the test. She is working on it now (in all her spare time which we need to be patient as she is very busy) and as soon as we have the information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Tracy N
To: gsp-l@shorthairs.net
Sent: Tuesday, September 13, 2011 3:14 PM
Subject: [gsp-l] Re: [gsp-l] Re: [gsp-l] LD test
In the event you do test and have a carrier, you should not breed it. There is no way of knowing, at this point in time, if you're truly breeding to a non-carrier and/or producing non-carriers. The gene has not been found. Sent from my Verizon Wireless Phone
In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time,
gspfreak@aol.com writes:
There is no definite "normal" either. Despite what the
results say.
So what is the point of doing it?
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bisgsp
SH
Posts:52
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| 11/04/2011 8:07 AM |
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Thank Leita!
Sent from my Verizon Wireless Phone
-----Original message-----
From: Leita Estes
To: "gsp-l@shorthairs.net"
Sent: Wed, Sep 14, 2011 03:42:08 GMT+00:00
Subject: Re: [gsp-l] very important real info about LD
This is a quote from Dr. Casal tonight. In short, we have found the gene and the mutation. The test that we
have been running for the past year is the mutation test not a marker
test. So our test is 99.99% accurate provided the samples have been
properly labeled.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Deirdre
To: "gsp-l@shorthairs.net"
Sent: Tuesday, September 13, 2011 7:09 PM
Subject: Re: [gsp-l] very important real info about LD
If my understanding is correct based on the research I do, when you state a 5%
margin of error you are referring to 95% confidence interval for the test. Correct? That is still only disclosing the margin of error for the marker, not the gene?
Sent from my iPhone
The test we have for LD at this time is the only test available and this disease is severe enough that not to test is very important for our breed it is something you as a breeder need to think very hard about. Would you really want to take the chance of producing affected
puppies because you didn't test?
Lets have a cool head about this and stop the negative comments until we have all the information from Dr. Casal. Dr. Casal is the expert not myself or the H&W committee or Katie Tazza so just be patient and
wait for scientific information rather that rumor or hearsay.
There are two types of genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This is what the CD test is
an indirect or marker test in which the actual gene is not
known but a piece of chromosome is associated with the disease. Marker tests
always have a range of error up to 5% depending on the distance from the actual
gene (in other words, the larger you cast your net on the chromosome, the
greater can be the error. This is what the LD test is.
The H&W committee has asked Dr. Casal if she would answer some questions for us about the development of the test and many other pertainent questions about the test. She is working on it now (in all her spare time which we need to be patient as she is very busy) and as soon as we have the information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Tracy N <gspfreak@aol.com>
To: gsp-l@shorthairs.net
Sent: Tuesday, September 13, 2011 3:14 PM
Subject: [gsp-l] Re: [gsp-l] Re: [gsp-l] LD test
In the event you do test and have a carrier, you should not breed it. There is no way of knowing, at this point in time, if you're truly breeding to a non-carrier and/or producing non-carriers. The gene has not been found. Sent from my Verizon Wireless Phone
In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time,
gspfreak@aol.com writes: There is no definite "normal" either. Despite what the
results say.
So what is the point of doing it?
|
|
|
|
|
shortales
MH
Posts:336
|
| 11/04/2011 8:09 AM |
|
You have to test both parents not just one. If both parents are clear the pups will be clear. But for example if one parent is a carrier and the other is clear then all the pups will need to be tested to see their status as they can be either clear or carrier.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Julie Lahr
To: "gsp-l@shorthairs.net"
Sent: Tuesday, September 13, 2011 7:51 PM
Subject: Re: [gsp-l] very important real info about LD
I was just thinking if I tested Pepper then I would have to test her babies.
If Pepper is clear then her pups could not be affected right? Sent from my iPhone...
Julie www.vonlahrheim.com
Leita, I would be interested in knowing how long ago the questions were sent to Dr. Casal? And how long you plan to wait for answers? I seems to me that quite a few of the GSP community have sent money for tests and we should expect timely answers to the H & W committees questions. I would also prefer to see the reply posted in its entirety on the website rather than wait months for the Journal article. Sunnie Fair
Date: Tue, 13 Sep 2011 16:47:28 -0700 From: shortales@rocketmail.comSubject: [gsp-l] very important real info about LD To: gsp-l@shorthairs.netThe test we have for LD at this time is the only test available and this disease is severe enough that not to test is very important for our breed it is something you as a breeder need to think very hard about. Would you really want to take the chance of producing affected puppies because you didn't test?
Lets have a cool head about this and stop the negative comments until we have all the information from Dr. Casal. Dr. Casal is
the expert not myself or the H&W committee or Katie Tazza so just be patient and
wait for scientific information rather that rumor or hearsay.
There are two types of genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This is what the CD test is
an indirect or marker test in which the actual gene is not
known but a piece of chromosome is associated with the disease. Marker tests
always have a range of error up to 5% depending on the distance from the actual
gene (in other words, the larger you cast your net on the chromosome, the
greater can be the error. This is what the LD test is.
The H&W committee has asked Dr. Casal if she would answer some questions for us about the development of the test and many other pertainent questions about the test. She is working on it now (in all her spare time which we need to be patient as she is very busy) and as soon as we have the information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Tracy N <gspfreak@aol.com>
To: gsp-l@shorthairs.net
Sent: Tuesday, September 13, 2011 3:14 PM
Subject: [gsp-l] Re: [gsp-l] Re: [gsp-l] LD test
In the event you do test and have a carrier, you should not breed it. There is no way of knowing, at this point in time, if you're truly breeding to a non-carrier and/or producing non-carriers. The gene has not been found. Sent from my Verizon Wireless Phone
In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time,
gspfreak@aol.com writes: There is no definite "normal" either. Despite what the
results say.
So what is the point of doing it?
|
|
|
|
|
LahrGSP
MH
Posts:703
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| 11/04/2011 8:09 AM |
|
In a message dated 9/13/2011 9:25:29 P.M. Pacific Daylight Time,
shortales@rocketmail.com writes:
You have to test both parents not just one. If both parents are
clear the pups will be clear. But for example if one parent is a carrier
and the other is clear then all the pups will need to be tested to see their
status as they can be either clear or carrier.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple
BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty
dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Julie Lahr
To:
"gsp-l@shorthairs.net"
Sent: Tuesday, September 13, 2011 7:51
PM
Subject: Re: [gsp-l] very
important real info about LD
I was just thinking if I tested Pepper then I would have to test her
babies.
If Pepper is clear then her pups could not be affected
right?
Yes, I knew that but I was just saying that if she was
clear they couldn't be affected. Like CD?
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bajnok
MH
Posts:67
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| 11/04/2011 8:09 AM |
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Have research and findings been published?
François
Bernier
Bajnok GSPs
www.bajnok.net
Sent: Tuesday, September 13, 2011 11:40 PM
Subject: Re: [gsp-l] very important real info about
LD
This is a quote from Dr. Casal tonight. In short, we have found the gene
and the mutation. The test that we have been running for the past year is the
mutation test not a marker test. So our test is 99.99% accurate provided the
samples have been properly labeled.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS,
BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog
(Dalmatian) Ch. Merry Go Rounds Match Point
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pbeachene1
JH
Posts:39
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| 11/04/2011 8:09 AM |
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Excuse my ignorance, I understand that this is an important disease that you are talking about, but what does LD stand for?
From: Deirdre
To: "gsp-l@shorthairs.net"
Sent: Tue, September 13, 2011 10:09:30 PM
Subject: Re: [gsp-l] very important real info about LD
If my understanding is correct based on the research I do, when you state a 5% margin of error you are referring to 95% confidence interval for the test. Correct? That is still only disclosing the margin of error for the marker, not the gene?
Sent from my iPhone
The test we have for LD at this time is the only test available and this disease is severe enough that not to test is very important for our breed it is something you as a breeder need to think very hard about. Would you
really want to take the chance of producing affected puppies because you didn't test?
Lets have a cool head about this and stop the negative comments until we have all the information from Dr. Casal. Dr. Casal is the expert not myself or the H&W committee or Katie Tazza so just be patient and
wait for scientific information rather that rumor or hearsay.
There are two types of genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This is what the CD test is
an indirect or marker test in which the actual gene is not
known but a piece of chromosome is associated with the disease. Marker tests
always have a range of error up to 5% depending on the distance from the actual
gene (in other words, the larger you cast your net on the chromosome, the
greater can be the error. This is what the LD test is.
The H&W committee has asked Dr. Casal if she would answer some questions for us about the development of the test and many other pertainent questions about the test. She is working on it now (in all her spare time which we need to be patient as she is very busy) and as soon as we have the information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Tracy N <gspfreak@aol.com>
To: gsp-l@shorthairs.net
Sent: Tuesday, September 13, 2011 3:14 PM
Subject: [gsp-l] Re: [gsp-l] Re: [gsp-l] LD test
In the event you do test and have a carrier, you should not breed it. There is no way of knowing, at this point in time, if you're truly breeding to a non-carrier and/or producing non-carriers. The gene has not been found. Sent from my Verizon Wireless Phone
In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time,
gspfreak@aol.com writes: There is no definite "normal" either. Despite what the
results say.
So what is the point of doing it?
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shortales
MH
Posts:336
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| 11/04/2011 8:15 AM |
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Lupoid Dematosis, please visit the GSPCA website link http://www.gspca.org/Health/lupoid-dermatosis.html for more information about the disease.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Paul Beauchene
To: gsp-l@shorthairs.net
Sent: Wednesday,
September 14, 2011 3:24 AM
Subject: Re: [gsp-l] very important real info about LD
Excuse my ignorance, I understand that this is an important disease that you are talking about, but what does LD stand for?
From: Deirdre
To: "gsp-l@shorthairs.net"
Sent: Tue, September 13, 2011 10:09:30 PM
Subject: Re: [gsp-l] very important real info about LD
If my understanding is correct based on the research I do, when you state a 5% margin of error you are referring to 95% confidence interval for the test. Correct? That is still only disclosing the margin of error for the marker, not the gene?
Sent from my iPhone
The test we have for LD at this time is the only test available and this disease is severe enough that not to test is very important for our breed it is something you as a breeder need to think
very hard about. Would you
really want to take the chance of producing affected puppies because you didn't test?
Lets have a cool head about this and stop the negative comments until we have all the information from Dr. Casal. Dr. Casal is the expert not myself or the H&W committee or Katie Tazza so just be patient and
wait for scientific information rather that rumor or hearsay.
There are two types of genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This is what the CD test is
an indirect or marker test in which the actual gene is not
known but a piece of chromosome is associated with the disease. Marker tests
always have a range of error up to 5% depending on the distance from the actual
gene (in other words, the larger you cast your net on the chromosome, the
greater can be the error. This is what the LD test is.
The H&W committee has asked Dr. Casal if she would answer some questions for us about the development of the test and many other pertainent questions about the test. She is working on it now (in all her spare time which we need to be patient as she is very busy) and as soon as we have the information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Tracy N <gspfreak@aol.com>
To: gsp-l@shorthairs.net
Sent: Tuesday, September 13, 2011 3:14 PM
Subject: [gsp-l] Re: [gsp-l] Re: [gsp-l] LD test
In the event you do test and have a carrier, you should not breed it. There is no way of knowing, at this point in time, if you're truly breeding to a non-carrier and/or producing non-carriers. The gene has not been found. Sent from my Verizon Wireless Phone
In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time,
gspfreak@aol.com writes: There is no definite "normal" either. Despite what the
results say.
So what is the point of doing it?
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pbeachene1
JH
Posts:39
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| 11/04/2011 8:17 AM |
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Thank you. I really hate people using abbreviations
and assuming everyone knows what they are talking about.
----- Original Message -----
Sent: Wednesday, September 14, 2011 12:47
PM
Subject: Re: [gsp-l] very important real
info about LD
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple
BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty
dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Paul Beauchene
To: gsp-l@shorthairs.net
Sent: Wednesday, September 14, 2011 3:24
AM
Subject: Re: [gsp-l] very
important real info about LD
Excuse my ignorance, I understand that this is an important disease that
you are talking about, but what does LD stand for?
From: Deirdre
To: "gsp-l@shorthairs.net"
Sent: Tue, September 13, 2011 10:09:30
PM
Subject: Re: [gsp-l] very
important real info about LD
If my understanding is correct based on the research I do, when you state
a 5% margin of error you are referring to 95% confidence interval for the
test. Correct? That is still only disclosing the margin of error for the
marker, not the gene?
Sent from my iPhone
The test we have for LD at this time
is the only test available and this
disease is severe enough that not to test is very important for our breed it
is something you as a breeder need to think very hard about. Would you
really want to take the chance of producing affected puppies because you
didn't test?
Lets have a
cool head about this and stop the negative comments until we have all the
information from Dr. Casal. Dr. Casal is the expert not myself or the
H&W committee or Katie Tazza so just be patient and wait
for scientific information rather that rumor or hearsay.
There are two types of
genetic tests:
a direct or gene based test wherein the actual gene is known and
the actual mutation identified. This is what
the CD test is
an indirect or marker test in which the actual gene is not known
but a piece of chromosome is associated with the disease. Marker tests
always have a range of error up to 5% depending on the distance from the
actual gene (in other words, the larger you cast your net on the chromosome,
the greater can be the error. This is
what the LD test is.
The H&W committee has asked
Dr. Casal if she would answer some questions for us about the development of
the test and many other pertainent questions about the test. She is working
on it now (in all her spare time which we need to be patient as she is very
busy) and as soon as we have the
information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple
BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1
Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Tracy N <gspfreak@aol.com>
To: gsp-l@shorthairs.net
Sent: Tuesday, September 13, 2011 3:14
PM
Subject: [gsp-l] Re:
[gsp-l] Re: [gsp-l] LD test
In the event you do test and have a carrier, you should
not breed it. There is no way of knowing, at this point in time, if you're
truly breeding to a non-carrier and/or producing non-carriers. The gene has
not been found. Sent from my Verizon Wireless Phone
In a message dated 9/13/2011 2:42:20 P.M. Pacific Daylight Time, gspfreak@aol.com writes: There is no definite "normal" either. Despite what the results
say.
So what is the point of doing it?
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singltrakshorthairs
JH
Posts:20
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| 11/04/2011 8:17 AM |
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Do we know if we can test from Frozen Semen like the CD or are we out of luck on that?
The test we have for LD at this time is
the only test available and this
disease is severe enough that not to test is very important for our breed it
is something you as a breeder need to think very hard about. Would you really
want to take the chance of producing affected puppies because you didn't
test?
Lets have a
cool head about this and stop the negative comments until we have all the
information from Dr. Casal. Dr. Casal is the expert not myself or the H&W
committee or Katie Tazza so just be patient and wait for
scientific information rather that rumor or hearsay.
There are two types of
genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This
is what the CD test is
an indirect or marker test in which the actual gene is
not known but a piece of chromosome is associated with the disease. Marker
tests always have a range of error up to 5% depending on the distance from the
actual gene (in other words, the larger you cast your net on the chromosome,
the greater can be the error. This is
what the LD test is.
The H&W committee has asked Dr.
Casal if she would answer some questions for us about the development of the
test and many other pertainent questions about the test. She is working on it
now (in all her spare time which we need to be patient as she is very
busy) and as soon as we have the
information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple
BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty
dog (Dalmatian) Ch. Merry Go Rounds Match Point |
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shortales
MH
Posts:336
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| 11/04/2011 8:19 AM |
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We are working on that.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty dog (Dalmatian) Ch. Merry Go Rounds Match Point
From: Phyllis McNall
To: gsp-l@shorthairs.net
Sent: Wednesday, September 14, 2011 1:00 PM
Subject: Re: [gsp-l] very important real info
about LD
Do we know if we can test from Frozen Semen like the CD or are we out of luck on that?
The test we have for LD at this time is
the only test available and this
disease is severe enough that not to test is very important for our breed it
is something you as a breeder need to think very hard about. Would you really
want to take the chance of producing affected puppies because you didn't
test?
Lets have a
cool head about this and stop the negative comments until we have all the
information from Dr. Casal. Dr. Casal is the expert not myself or the H&W
committee or Katie Tazza so just be patient and wait for
scientific information rather that rumor or hearsay.
There are two types of
genetic tests:
a direct or gene based test wherein the actual gene is
known and the actual mutation identified. This
is what the CD test is
an indirect or marker test in which the actual gene is
not known but a piece of chromosome is associated with the disease. Marker
tests always have a range of error up to 5% depending on the distance from the
actual gene (in other words, the larger you cast your net on the chromosome,
the greater can be the error. This is
what the LD test is.
The H&W committee has asked Dr.
Casal if she would answer some questions for us about the development of the
test and many other pertainent questions about the test. She is working on it
now (in all her spare time which we need to be patient as she is very
busy) and as soon as we have the
information we will publish it in the Journal.
Leita Estes Shortales German Shorthaired Pointers
Home of Multiple
BIS, BISS GCh Shortales N Cahoots W Irondale, JH
# 1 GSP 2011
1 Spotty
dog (Dalmatian) Ch. Merry Go Rounds Match Point |
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